Development of an Effective Therapy for Chronic Myelogenous Leukemia
نویسندگان
چکیده
منابع مشابه
Development of an effective therapy for chronic myelogenous leukemia.
Targeted small-molecule drugs have revolutionized treatment of chronic myeloid leukemia (CML) during the last decade. These agents interrupt a constitutively active BCR-ABL, the causative agent for CML, by interfering with adenosine 5' triphosphate-dependent ABL tyrosine kinase. Although the efficacy of tyrosine kinase inhibitors (TKIs) has resulted in overall survival of greater than 90%, TKIs...
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even clinical relapses sometimes occurring as late as 5 to 10 T years after transplantation is being recognized in recipients HE TERM CHRONIC myelogenous leukemia (CML) belies the insidious, unsparing course of this lethal of either T-lymphocyte–depleted or unmanipulated grafts. hematopoietic malignancy. In CML, the malignant transforInterferon-a (IFN-a) therapy for CML. Therapy of mation of a ...
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15 صفحه اولimatinib therapy in chronic myelogenous leukemia and thyroid function tests.
introduction: imatinib, a tyrosine kinase inhibitor which resulted in much improvement in the treatment of chronic myelogenous leukemia (cml), may adversely affect thyroid gland function. to date, assessment of thyroid function during imatinib therapy has limited to retrospective studies. the aim of this study was to evaluate the effects of imatinib on thyroid function in a prospective manner. ...
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Chronic myelogenous leukemia (CML) is a clonal proliferative disease originating from a pluripotential stem cell in which a 9:22 translocation, Philadelphia (Ph) chromosome, results in the production of BCR-ABL fusion protein that has constitutive tyrosine kinase activity and deregulates signal transduction pathways, thus causing leukemia. The natural course of CML is usually triphasic (chronic...
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ژورنال
عنوان ژورنال: The Cancer Journal
سال: 2011
ISSN: 1528-9117
DOI: 10.1097/ppo.0b013e318237e5b7